By obtaining 'Nick Tickets', Juliet can activate the 'Nick Roulette' in which various moves can be performed using Nick's head, such as a bombarding attack or making masses of zombies groggy. At certain points in the game, Nick's head can be attached to a decapitated zombie's body, during which the player will rhythmically press buttons in order to have him move about and clear the way for Juliet. Throughout her journey, Juliet is accompanied by her boyfriend, Nick, who is a disembodied head hanging from her waist. Juliet will die if she loses all her health or fails certain scenarios, though, in the case of the former, Juliet may be able to come back to life by winning a roulette spin. The maximum number of lollipops Juliet can hold depends on the difficulty setting. Throughout the game, Juliet can also collect lollipops which allow her to recover health. As the game progresses, Juliet will also receive the Chainsaw Dash, which allows her to charge with her chainsaw and fly off-ramps, and the Chainsaw Blaster, a long-range weapon used for blasting enemies and obstacles. Sparkle Hunting is achieved when Juliet kills three or more zombies simultaneously or in quick succession and rewards platinum medals that can be spent on other goodies such as unlockable costumes, music, and artwork. These medals can be spent at Chop2Shop.zom stores found throughout each level where Juliet can purchase new moves and combos, as well as items that can increase her stats. Gold medals can be earned by defeating zombies, smashing objects, and rescuing classmates. Zombies can be beaten into a groggy state, during which they can instantly be killed with a chainsaw attack. Juliet can use melee attacks, dodges and high and low attacks with her chainsaw. Lollipop Chainsaw is a hack-and-slash video game in which players play as Juliet as she fights through hordes of zombies.

In July 2022, Kadokawa Games successor Dragami Games announced a remake titled Lollipop Chainsaw RePOP set to launch sometime in 2024. It features Juliet Starling (voiced by Tara Strong in English and by both Eri Kitamura in the PlayStation 3 version and Yoko Hikasa in the Xbox version in Japanese), a cheerleader zombie hunter fighting zombies in a fictional California high school. Interactive Entertainment internationally in 2012. A collaboration between game designer Goichi Suda (also known by his nickname Suda51) and filmmaker James Gunn, it was released by Kadokawa Games in Japan and Warner Bros. Lollipop Chainsaw is a 2012 action-adventure hack-and-slash video game developed by Grasshopper Manufacture for the PlayStation 3 and Xbox 360.

Lollipop chainsaw cosplay